Applications are now open for Queensland musicians to enter the 100 Songs Project.

Selected bands and songwriters will be invited to lay down an original track with the aim to record 100 songs in 100 hours.

The project was launched last year as part of the QUT's Independent Music Project and will run again this year from May 20-25.

Project Head Professor Phil Graham says that 100 Songs is the key activity of the QUT project, which was formed to contribute meaningfully to the music industry.

"100 Songs lets us look at new models of doing business and creating real music with real artists and showing that locking musicians and other creatives in a room for 100 hours can result in some amazing music," he says.

Last year 72 acts were chosen to participate out of over 400 applicants and the 12 best songs will be released on a compilation album later this month.

Artist's songs will be sent to Triple J and 4ZZZ for broadcast consideration and the best songs will be released internationally by MGM.

Applications for the 100 Songs Project close midnight Monday April 9.

The 100 Songs Project and the Twelve compilation album will be launched at the Brisbane Powerhouse with performances by Cold & Need and Brianna Carpenter on March 31.